Key words: supercritical carbon dioxide, aliphatic polyethers, matrixes for tissue engineering
A novel method for fabrication of highly porous bioresorbable polymer matrixes for tissue engineering is proposed and developed. It is shown that injection of polymer compositions plasticized in sub- or supercritical carbon dioxide at 20—40 °C through the nozzle of certain diameter to the moulds at atmospheric or elevated (up to 6 MPa) CO2 pressure enables to fabricate highly reproducible polymer matrixes with desirable structure and morphology and mean porosity up to 96 % without use of organic solvents. The effect of chemical composition and molecular weight of initial polymers, as well as, carbon dioxide temperature and pressure in reaction and receiver chambers onto the morphology and internal structure of fabricated matrixes is studied using a scanning electron microscopy.
doi:10.1134/S1990793113080034